合成生物学应用——医疗Biotechnol Adv. 2024 Mar 1:108336. doi:
10.1016/j.biotechadv.2024.108336.下一代益生菌:工程活生物疗法。Next
generation probiotics: Engineering live biotherapeutics.Murali SK(1), Mansell TJ(2).Author information: (1)Department of
chemical and biological engineering, Iowa State University, Ames, IA 50011,
USA. Electronic address: sanjeev@iastate.edu. (2)Department of chemical and
biological engineering, Iowa State University, Ames, IA 50011, USA. Electronic
address: mansell@iastate.edu.人类微生物群的种群动态与炎症性肠病、癌症、肥胖、自身免疫性疾病和许多其他人类疾病状态有关。一种新兴的治疗范例是使用活的工程生物体,即所谓的下一代益生菌。然而,这些微生物疗法的功效可能会受到微生物在肠道恶劣和营养有限的环境中的整体表现的限制。本文综述了细菌和酵母菌作为益生菌的应用现状,重点介绍了在这些生物中用于
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