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一个计算同义突变(Ks)与非同义突变(Ka)的方法

生信百科  · 公众号  · 医学  · 2017-10-31 07:00
Ka,Ks 的概念和意义Ks(synonymous substitutions):同义替换,即一个密码子中碱基的突变不改变该密码子编码的氨基酸。Ka(nonsynonymous substitutions):非同义替换,即一个密码子中碱基的突变改变该密码子编码的氨基酸。dN/dS 相当于 Ka/Ks,其意义如下:Neutral Evolution (drift): dN/dS ratio = 1 implies there has been equal numbers of synonymous (dna substitutions that do not affect the protein sequence) and non-synonymous changes (dna substitutions that do affect the protein sequence) during the time between ancestral to the modern versions of the protein.Positive Selection (adaptive evolution): dN/dS ratio > 1 implies there has been more non-synonymous changes than synonymous changes. There has been evolutionary pressure to escape from the ancestral state - i.e. positive selection pressure. This ca ………………………………

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