00 文章信息英文标题：Ect2-Dependent rRNA Synthesis Is Required for KRAS-TRP53-Driven Lung Adenocarcinoma中文标题：Ect2依赖的rRNA合成是KRAS-TRP53驱动的肺腺癌所必需的期刊：《Cancer Cell》影响因子：26.602 发表时间：2017 Feb 13研究领域：肿瘤DOI号：10.1016/j.ccell.2016.12.01001 文献概述In BriefJustilien et al. reveal that the guanine nucleotide exchange factor Ect2 is required for tumor initiation in a nonsmall-cell lung carcinoma model and uncover a nuclear role for Ect2 in promoting rDNA transcription, which is important for transformation, through a mechanism involving Rac1, NPM, and UBF1.译文：Justilen等人。揭示了鸟嘌呤核苷酸交换因子ect2在非小细胞肺癌模型中是肿瘤启动所必需的，并揭示了ect2通过一种涉及rac1、NPM和UBF1的机制在促进rDNA转录中的核作用，而rDNA转
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