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SCI 22 November 2024 Genetic and epigenetic bases of long-term adverse effects of childhood cancer therapy (Nature Reviews Cancer, IF: 72.5) Zhaoming Wang & Jinghui Zhang CORRESPONDENCE TO: zhaoming.wang@stjude.org; jinghui.zhang@stjude.org Abstract 摘要 Over the past decade, genome-scale molecular profiling of large childhood cancer survivorship cohorts has led to unprecedented advances in our understanding of the genetic and epigenetic bases of therapy-related adverse health outcomes in this vulnerable population. To facilitate the integration of knowledge generated from these studies into formulating next-generation precision care for survivors of childhood cancer, we summarize key findings of genetic and epigenetic association studies of long-term therapy-related adverse effects including subsequent neoplasms and cardiomyopathies among others. We also discuss therapy-related genotoxicities including clonal haematopoiesis and DNA methylation, which may underlie accelerated mole
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